The Interaction-Interaction Model for Disease Protein Discovery

Network medicine, the field of using biological networks to develop insight into disease and medicine, is a budding area of research where current efforts have been rewarded with only a middling level of success. Various network models have been proposed to help advise and direct medical research; this paper explores the possible utility of the ”interaction-interaction” (II) network model by adapting some current protein-protein-interaction (PPI) algorithms and comparing the performance amongst algorithms over the II and PPI networks.